JAK2 exon 12 mutant mice display isolated erythrocytosis and changes in iron metabolism favoring increased erythropoiesis-Reference-Cited by-同舟云学术

JAK2 exon 12 mutant mice display isolated erythrocytosis and changes in iron metabolism favoring increased erythropoiesis

Published:2016-08-11 Issue:6 Volume:128 Page:839-851
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Grisouard Jean¹,Li Sai¹,Kubovcakova Lucia¹,Rao Tata Nageswara¹,Meyer Sara C.¹,Lundberg Pontus¹,Hao-Shen Hui¹,Romanet Vincent²,Murakami Masato²,Radimerski Thomas²,Dirnhofer Stephan³,Skoda Radek C.¹

Affiliation:

1. Department of Biomedicine, Experimental Hematology, University Hospital Basel, Basel, Switzerland;

2. Disease Area Oncology, Novartis Institutes for Biomedical Research, Basel, Switzerland; and

3. Institute of Pathology, University Hospital Basel, Basel, Switzerland

Abstract

Key Points Mice expressing a JAK2 exon 12 mutation display isolated erythrocytosis similar to the majority of patients with JAK2 exon 12 mutations. JAK2 exon 12 mutation induces changes in iron metabolism that increase iron availability to allow maximal production of red cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/6/839/1398408/839.pdf

Reference38 articles.

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4. A gain-of-function mutation of JAK2 in myeloproliferative disorders.;Kralovics;N Engl J Med,2005

5. JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis.;Scott;N Engl J Med,2007

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