Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genes

Author:

Koide Shuhei1,Oshima Motohiko1,Takubo Keiyo2,Yamazaki Satoshi3,Nitta Eriko1,Saraya Atsunori1,Aoyama Kazumasa1,Kato Yuko1,Miyagi Satoru1,Nakajima-Takagi Yaeko1,Chiba Tetsuhiro4,Matsui Hirotaka5,Arai Fumio6,Suzuki Yutaka7,Kimura Hiroshi8,Nakauchi Hiromitsu39,Suda Toshio1011,Shinkai Yoichi12,Iwama Atsushi1

Affiliation:

1. Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan;

2. Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan;

3. Division of Stem Cell Therapy, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan;

4. Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan;

5. Department of Molecular Laboratory Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan;

6. Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;

7. Laboratory of Functional Genomics, Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan;

8. Department of Biological Sciences, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan;

9. Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA;

10. Cancer Science Institute, National University of Singapore, Singapore, Singapore;

11. International Research Center for Medical Sciences, Kumamoto University, Kumamoto City, Japan; and

12. Cellular Memory Laboratory, RIKEN, Wako, Japan

Abstract

Key Points Setdb1, an H3K9 histone methyltransferase, is essential for the maintenance of HSPCs. Setdb1 restricts the activation of nonhematopoietic genes, such as gluconeogenic pathway genes, to maintain HSPCs.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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