Persistence of long-lived plasma cells and humoral immunity in individuals responding to CD19-directed CAR T-cell therapy-Reference-Cited by-同舟云学术

Persistence of long-lived plasma cells and humoral immunity in individuals responding to CD19-directed CAR T-cell therapy

Published:2016-07-21 Issue:3 Volume:128 Page:360-370
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Bhoj Vijay G.¹^ORCID,Arhontoulis Dimitrios¹,Wertheim Gerald²,Capobianchi James³,Callahan Colleen A.⁴,Ellebrecht Christoph T.⁵,Obstfeld Amrom E.¹,Lacey Simon F.¹,Melenhorst Jan J.¹,Nazimuddin Farzana¹,Hwang Wei-Ting⁶,Maude Shannon L.⁴,Wasik Mariusz A.¹^ORCID,Bagg Adam¹,Schuster Stephen³,Feldman Michael D.¹,Porter David L.³,Grupp Stephen A.⁴,June Carl H.¹,Milone Michael C.¹^ORCID

Affiliation:

1. Department of Pathology and Laboratory Medicine, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA;

2. Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA;

3. Department of Medicine, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA;

4. Division of Bone Marrow Transplantation, Children’s Hospital of Philadelphia, Philadelphia, PA; and

5. Department of Dermatology and

6. Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA

Abstract

Key PointsCD19-targeted T-cell immunotherapy reveals that a population of PCs lacking CD19 expression survives long-term, independent of B cells. Preexisting humoral immunity to vaccine-related antigens can persist in patients despite marked B-cell aplasia after CTL019 immunotherapy.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/3/360/1359006/360.pdf

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5. Maintenance of long-lived plasma cells and serological memory despite mature and memory B cell depletion during CD20 immunotherapy in mice.;DiLillo;J Immunol,2008

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