T cells lacking HDAC11 have increased effector functions and mediate enhanced alloreactivity in a murine model-Reference-Cited by-同舟云学术

T cells lacking HDAC11 have increased effector functions and mediate enhanced alloreactivity in a murine model

Published:2017-07-13 Issue:2 Volume:130 Page:146-155
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Woods David M.¹²,Woan Karrune V.¹,Cheng Fengdong¹³,Sodré Andressa L.¹²,Wang Dapeng¹,Wu Yongxia⁴,Wang Zi¹,Chen Jie¹³,Powers John¹,Pinilla-Ibarz Javier¹,Yu Yu¹,Zhang Ya⁴,Wu Xuefeng⁴,Zheng Xiaoyan⁴,Weber Jeffrey¹²,Hancock Wayne W.⁵,Seto Edward³,Villagra Alejandro³,Yu Xue-Zhong⁶,Sotomayor Eduardo M.³

Affiliation:

1. H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL;

2. Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY;

3. Department of Medicine and

4. Department of Anatomy and Regenerative Biology, George Washington Cancer Center, Washington, DC;

5. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; and

6. Department of Microbiology & Immunology, Medical University of South Carolina, Charleston, SC

Abstract

Key Points T cells from HDAC11KO mice have increased effector functions and mediate more rapid and potent GVHD. HDAC11 associates with the Eomes and Tbet gene promoter regions in resting cells and disassociates upon activation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/130/2/146/1403907/blood731505.pdf

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