Adhesion of Staphylococcus aureus to the vessel wall under flow is mediated by von Willebrand factor

Adhesion of Staphylococcus aureus to the vessel wall under flow is mediated by von Willebrand factor–binding protein

Published:2014-09-04 Issue:10 Volume:124 Page:1669-1676
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Claes Jorien¹,Vanassche Thomas¹,Peetermans Marijke¹,Liesenborghs Laurens¹,Vandenbriele Christophe¹,Vanhoorelbeke Karen²,Missiakas Dominique³,Schneewind Olaf³,Hoylaerts Marc F.¹,Heying Ruth¹⁴,Verhamme Peter¹

Affiliation:

1. Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, and

2. Laboratory for Thrombosis Research, Interdisciplinary Research Facility Life Sciences, Kulak, Katholieke Universiteit Leuven, Leuven, Belgium;

3. Department of Microbiology, University of Chicago, IL; and

4. Cardiovascular Developmental Biology, Department of Cardiovascular Sciences, Katholieke Universiteit Leuven, Leuven, Belgium

Abstract

Key PointsvWbp mediates adhesion of S aureus under flow to activated endothelial cells and the subendothelium via VWF. vWbp activates prothrombin and triggers the formation of bacteria–fibrin–platelet aggregates, which enhance adhesion to vessels under flow.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/10/1669/1380133/1669.pdf

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4. The von Willebrand factor-binding protein (vWbp) of Staphylococcus aureus is a coagulase.;Bjerketorp;FEMS Microbiol Lett,2004

5. Biochemistry and genetics of von Willebrand factor.;Sadler;Annu Rev Biochem,1998

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