Benefit of high-dose daunorubicin in AML induction extends across cytogenetic and molecular groups

Author:

Luskin Marlise R.1,Lee Ju-Whei2,Fernandez Hugo F.3,Abdel-Wahab Omar45,Bennett John M.6,Ketterling Rhett P.7,Lazarus Hillard M.8,Levine Ross L.45,Litzow Mark R.9,Paietta Elisabeth M.10,Patel Jay P.4,Racevskis Janis10,Rowe Jacob M.11,Tallman Martin S.5,Sun Zhuoxin2,Luger Selina M.1

Affiliation:

1. Division of Hematology and Oncology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA;

2. Eastern Cooperative Oncology Group–American College of Radiology Imaging Network Biostatistics Center, Dana-Farber Cancer Institute, Boston, MA;

3. Department of Blood and Marrow Transplantation, Moffitt Cancer Center, Tampa, FL;

4. Human Oncology and Pathogenesis Program, and

5. Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY;

6. Department of Pathology, University of Rochester, Rochester, NY;

7. Division of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN;

8. Seidman Cancer Center, Case Western Reserve University, Cleveland, OH;

9. Department of Hematology, Mayo Clinic, Rochester, MN;

10. Department of Oncology, Montefiore Medical Center, Bronx, NY; and

11. Rambam Medical Center, Haifa, Israel

Abstract

Key Points High-dose daunorubicin benefits AML patients with favorable and intermediate cytogenetics and with FLT3-ITD, NPM1, and DNMT3A mutations. High-dose daunorubicin is required for the favorable impact of the NPM1 mutation in AML.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3