TGF-β–induced intracellular PAI-1 is responsible for retaining hematopoietic stem cells in the niche-Reference-Cited by-同舟云学术

TGF-β–induced intracellular PAI-1 is responsible for retaining hematopoietic stem cells in the niche

Published:2017-11-23 Issue:21 Volume:130 Page:2283-2294
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Yahata Takashi¹²,Ibrahim Abd Aziz¹³,Muguruma Yukari¹³,Eren Mesut⁴,Shaffer Alexander M.⁴,Watanabe Nobuo¹,Kaneko Satoko¹²,Nakabayashi Tetsuo⁵,Dan Takashi⁵,Hirayama Noriaki⁶,Vaughan Douglas E.⁴,Miyata Toshio⁵,Ando Kiyoshi¹³

Affiliation:

1. Research Center for Regenerative Medicine,

2. Department of Cell Transplantation and Regenerative Medicine, and

3. Department of Hematology and Oncology, Tokai University School of Medicine, Kanagawa, Japan;

4. Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL;

5. United Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Miyagi, Japan; and

6. Institute of Advanced Biosciences, Tokai University, Kanagawa, Japan

Abstract

Key PointsTGF-β–induced intracellular PAI-1 regulates the balance of HSPCs localization between BM and periphery. Intracellular PAI-1 inhibits Furin-dependent maturation of MT1-MMP in HSPCs, resulting in the suppression of HSPC motility.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/130/21/2283/1403441/blood767384.pdf

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