Human and viral interleukin-6 and other cytokines in Kaposi sarcoma herpesvirus-associated multicentric Castleman disease-Reference-Cited by-同舟云学术

Human and viral interleukin-6 and other cytokines in Kaposi sarcoma herpesvirus-associated multicentric Castleman disease

Published:2013-12-19 Issue:26 Volume:122 Page:4189-4198
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Polizzotto Mark N.¹,Uldrick Thomas S.¹,Wang Victoria¹,Aleman Karen¹,Wyvill Kathleen M.¹,Marshall Vickie²,Pittaluga Stefania³,O’Mahony Deirdre¹,Whitby Denise²,Tosato Giovanna⁴,Steinberg Seth M.⁵,Little Richard F.¹,Yarchoan Robert¹

Affiliation:

1. HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD;

2. Viral Oncology Section, AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD; and

3. Laboratory of Pathology,

4. Laboratory of Cellular Oncology, and

5. Biostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute, Bethesda, MD

Abstract

Key PointsHuman IL-6 and a viral IL-6 homolog encoded by KSHV/HHV8 can independently or together lead to flares of KSHV-associated MCD. KSHV-MCD disease flares were more severe where both human and viral IL-6 were elevated, suggesting they jointly contribute to severity.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/26/4189/1372220/4189.pdf

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