Human circadian system causes a morning peak in prothrombotic plasminogen activator inhibitor-1 (PAI-1) independent of the sleep/wake cycle-Reference-Cited by-同舟云学术

Human circadian system causes a morning peak in prothrombotic plasminogen activator inhibitor-1 (PAI-1) independent of the sleep/wake cycle

Published:2014-01-23 Issue:4 Volume:123 Page:590-593
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Scheer Frank A. J. L.¹,Shea Steven A.¹²

Affiliation:

1. Medical Chronobiology Program, Division of Sleep Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston, MA; and

2. Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR

Abstract

Key Points The human circadian system causes a morning peak in circulating levels of PAI-1, independent of any behavioral or environmental influences. The circadian system determines to a large extent the PAI-1 rhythm observed during a regular sleep/wake cycle.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/4/590/1378605/590.pdf

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4. Concurrent morning increase in platelet aggregability and the risk of myocardial infarction and sudden cardiac death.;Tofler;N Engl J Med,1987

5. CLIF, a novel cycle-like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression.;Maemura;J Biol Chem,2000

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