Time-resolved characterization of cAMP/PKA-dependent signaling reveals that platelet inhibition is a concerted process involving multiple signaling pathways

Author:

Beck Florian1,Geiger Jörg2,Gambaryan Stepan23,Veit Johannes4,Vaudel Marc1,Nollau Peter5,Kohlbacher Oliver4,Martens Lennart67,Walter Ulrich8,Sickmann Albert19,Zahedi René P.1

Affiliation:

1. Leibniz-Institut für Analytische Wissenschaften–ISAS–e.V., Dortmund, Germany;

2. Institut für Klinische Biochemie und Pathobiochemie, Universitätsklinikum Würzburg, Würzburg, Germany;

3. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, S. Petersburg, Russia;

4. Center for Bioinformatics, Universität Tübingen, Tübingen, Germany;

5. Institute of Clinical Chemistry, University Medical Center Hamburg–Eppendorf, Hamburg, Germany;

6. Department of Medical Protein Research, Vlaams Instituut voor Biotechnologie, Ghent, Belgium;

7. Department of Biochemistry, Ghent University, Ghent, Belgium;

8. Center for Thrombosis & Hemostasis, Universitätsklinikum der Johannes Gutenberg-Universität Mainz, Mainz, Germany; and

9. Medizinisches Proteom-Center, Ruhr-Universität, Bochum, Germany

Abstract

Key Points First comprehensive and time-resolved characterization of platelet cAMP/PKA signaling upon iloprost treatment. More than 2700 phosphorylation sites quantified between 4 time points and from 3 individual healthy donors.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference50 articles.

1. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation.;Moncada;Nature,1976

2. Purification and properties of prostaglandin E1/prostacyclin receptor of human blood platelets.;Dutta-Roy;J Biol Chem,1987

3. Novel roles of cAMP/cGMP-dependent signaling in platelets.;Smolenski;J Thromb Haemost,2012

4. Human platelet pathology related to defects in the G-protein signaling cascade.;Van Geet;J Thromb Haemost,2009

5. Thromboxane, prostacyclin and isoprostanes: therapeutic targets in atherogenesis.;Dogné;Trends Pharmacol Sci,2005

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