Both primitive and definitive blood cells are derived from Flk-1+ mesoderm-Reference-Cited by-同舟云学术

Both primitive and definitive blood cells are derived from Flk-1+ mesoderm

Published:2009-01-15 Issue:3 Volume:113 Page:563-566
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Lugus Jesse J.¹²,Park Changwon¹,Ma Yunglin D.¹³,Choi Kyunghee¹²³

Affiliation:

1. Department of Pathology and Immunology,

2. Molecular Cell Biology Program, and

3. Developmental Biology Program, Washington University School of Medicine, St Louis, MO

Abstract

AbstractEmerging evidence suggests that all hematopoietic and endothelial cells originate from Flk-1+ mesoderm in the mouse. However, this concept has not been completely proven, especially for the origin of blood cells. Using either Flk1+/Cre;Rosa26R-EYFP or Flk1+/Cre;Rosa26R-LacZ mice, we permanently marked Flk-1+ cells and their progenies to determine the relationship between hematopoietic tissues and cells that express Flk-1. In embryos, all blood cells within the yolk sac and aorta were of Flk-1+ origin. In addition, nearly all CD45+ cells in bone marrow and circulating blood in adults were of Flk-1+ origin. These results provide clear evidence that all blood cells, primitive and definitive, in mice are derived from Flk-1+ mesodermal cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/113/3/563/1485959/zh800309000563.pdf

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