CRISPR/Cas9-mediated conversion of human platelet alloantigen allotypes-Reference-Cited by-同舟云学术

CRISPR/Cas9-mediated conversion of human platelet alloantigen allotypes

Published:2016-02-11 Issue:6 Volume:127 Page:675-680
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Zhang Nanyan¹,Zhi Huiying¹,Curtis Brian R.¹,Rao Sridhar¹²,Jobaliya Chintan³,Poncz Mortimer⁴,French Deborah L.³⁵,Newman Peter J.¹⁶⁷

Affiliation:

1. Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI;

2. Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI;

3. Center for Cellular and Molecular Therapeutics,

4. Department of Pediatrics, and

5. Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA; and

6. Department of Pharmacology and

7. Department of Cell Biology, Medical College of Wisconsin, Milwaukee, WI

Abstract

Key Points The genome of iPSCs has been edited to encode antigenically-distinct human platelet alloantigens. The iPSC-derived megakaryocyte progenitor cells express the designed alloantigens for diagnostic, investigative, and future therapeutic use.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/6/675/1394419/675.pdf

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5. Very early intracranial haemorrhage in alloimmune fetal thrombocytopenia.;Giovangrandi;Lancet,1990

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