Integrated genomic DNA/RNA profiling of hematologic malignancies in the clinical setting-Reference-Cited by-同舟云学术

Integrated genomic DNA/RNA profiling of hematologic malignancies in the clinical setting

Published:2016-06-16 Issue:24 Volume:127 Page:3004-3014
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

He Jie¹,Abdel-Wahab Omar²³,Nahas Michelle K.¹,Wang Kai¹,Rampal Raajit K.²³,Intlekofer Andrew M.⁴⁵,Patel Jay³,Krivstov Andrei⁴⁶⁷,Frampton Garrett M.¹,Young Lauren E.¹,Zhong Shan¹,Bailey Mark¹,White Jared R.¹,Roels Steven¹,Deffenbaugh Jason¹,Fichtenholtz Alex¹,Brennan Timothy¹,Rosenzweig Mark¹,Pelak Kimberly¹,Knapp Kristina M.⁶,Brennan Kristina W.¹,Donahue Amy L.¹,Young Geneva¹,Garcia Lazaro¹,Beckstrom Selmira T.¹,Zhao Mandy¹,White Emily¹,Banning Vera¹,Buell Jamie¹,Iwanik Kiel¹,Ross Jeffrey S.¹,Morosini Deborah¹,Younes Anas⁵,Hanash Alan M.⁸,Paietta Elisabeth⁹,Roberts Kathryn¹⁰,Mullighan Charles¹⁰,Dogan Ahmet¹¹,Armstrong Scott A.⁴⁶⁷,Mughal Tariq¹¹²,Vergilio Jo-Anne¹,Labrecque Elaine¹,Erlich Rachel¹,Vietz Christine¹,Yelensky Roman¹,Stephens Philip J.¹,Miller Vincent A.¹,van den Brink Marcel R. M.⁸¹³,Otto Geoff A.¹,Lipson Doron¹,Levine Ross L.²³⁶

Affiliation:

1. Foundation Medicine, Cambridge, MA;

2. Leukemia Service, Department of Medicine,

3. Human Oncology and Pathogenesis Program,

4. Cancer Biology and Genetics Program,

5. Lymphoma Service, Department of Medicine,

6. Leukemia Center,

7. Department of Pediatrics, and

8. Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY;

9. Department of Medicine (Oncology), Albert Einstein College of Medicine, Yeshiva University, New York, NY;

10. Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN;

11. Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY;

12. Division of Hematology and Oncology, Tufts University Medical Center, Boston, MA; and

13. Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY

Abstract

Key Points Novel clinically available comprehensive genomic profiling of both DNA and RNA in hematologic malignancies. Profiling of 3696 clinical hematologic tumors identified somatic alterations that impact diagnosis, prognosis, and therapeutic selection.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/24/3004/1394432/3004.pdf

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