The ability to cross the blood–cerebrospinal fluid barrier is a generic property of acute lymphoblastic leukemia blasts-Reference-Cited by-同舟云学术

The ability to cross the blood–cerebrospinal fluid barrier is a generic property of acute lymphoblastic leukemia blasts

Published:2016-04-21 Issue:16 Volume:127 Page:1998-2006
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Williams Mark T. S.¹,Yousafzai Yasar M.¹²^ORCID,Elder Alex³,Rehe Klaus³⁴,Bomken Simon³⁴^ORCID,Frishman-Levy Liron⁵⁶,Tavor Sigal⁷,Sinclair Paul³,Dormon Katie³,Masic Dino³,Perry Tracey⁸,Weston Victoria J.⁸,Kearns Pamela⁸,Blair Helen³,Russell Lisa J.³,Heidenreich Olaf³,Irving Julie A. E.³,Izraeli Shai⁵⁶,Vormoor Josef³⁴,Graham Gerard J.¹,Halsey Christina⁹¹⁰^ORCID

Affiliation:

1. Centre for Immunobiology, Institute of Infection, Immunity, and Inflammation, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, United Kingdom;

2. Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan;

3. Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom;

4. Department of Paediatric and Adolescent Haematology and Oncology, Great North Children’s Hospital, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, United Kingdom;

5. Functional Genomics and Childhood Leukemia Research Center, Safra Children's Hospital, Sheba Medical Center, Tel-Hashomer, Ramat Gan, Israel;

6. Department of Human Molecular Genetics and Biochemistry, Sackler Medical School, Tel Aviv University, Tel Aviv, Israel;

7. Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, Jerusalem, Israel;

8. Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom;

9. Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, United Kingdom; and

10. Department of Paediatric Haematology, Royal Hospital for Children, Glasgow, United Kingdom

Abstract

Key Points More than 75% of primary diagnostic BCP-ALL samples engraft in the CNS in xenograft models. We find no evidence for selective trafficking to the CNS but show that CNS entry is a generic property of BCP-ALL cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/16/1998/1392908/1998.pdf

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