Biological significance of HLA locus matching in unrelated donor bone marrow transplantation

Author:

Morishima Yasuo1,Kashiwase Koichi2,Matsuo Keitaro3,Azuma Fumihiro2,Morishima Satoko4,Onizuka Makoto5,Yabe Toshio2,Murata Makoto6,Doki Noriko7,Eto Tetsuya8,Mori Takehiko9,Miyamura Koichi10,Sao Hiroshi11,Ichinohe Tatsuo12,Saji Hiroo13,Kato Shunichi14,Atsuta Yoshiko1516,Kawa Keisei17,Kodera Yoshihisa18,Sasazuki Takehiko19

Affiliation:

1. Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan;

2. Japanese Red Cross Kanto-Koshinetsu Block Blood Center, Tokyo, Japan;

3. Department of Preventive Medicine, Kyushu University School of Medicine, Fukuoka, Japan;

4. Department of Hematology, Fujita Health University School of Medicine, Toyoake, Japan;

5. Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan;

6. Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan;

7. Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan;

8. Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan;

9. Division of Hematology, Keio University School of Medicine, Tokyo, Japan;

10. Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan;

11. Department of Hematology, Meitetsu Hospital, Nagoya, Japan;

12. Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan;

13. HLA Laboratory, Kyoto, Japan;

14. Department of Cell Transplantation, Tokai University School of Medicine, Isehara, Japan;

15. Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan;

16. Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan;

17. Japanese Red Cross Kinki Block Blood Center, Osaka, Japan;

18. Department of Promotion for Blood and Marrow Transplantation, Aichi Medical University, Aichi, Japan; and

19. Institute for Advanced Study, Kyushu University, Fukuoka, Japan

Abstract

Key Points Significant HLA locus mismatches responsible for transplant-related events were determined in 7898 unrelated marrow donor transplants. This information provides a rationale for use of an algorithm for unrelated donor selection.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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