COX-1–derived thromboxane A2 plays an essential role in early B-cell development via regulation of JAK/STAT5 signaling in mouse-Reference-Cited by-同舟云学术

COX-1–derived thromboxane A2 plays an essential role in early B-cell development via regulation of JAK/STAT5 signaling in mouse

Published:2014-09-04 Issue:10 Volume:124 Page:1610-1621
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Yang Qiong¹,Shi Maohua¹,Shen Yujun²,Cao Yingjiao¹,Zuo Shengkai²,Zuo Caojian²,Zhang Hui¹³,Gabrilovich Dmitry I.⁴,Yu Ying²,Zhou Jie¹³

Affiliation:

1. Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China;

2. Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China;

3. Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Chinese Ministry of Education, Guangzhou, China; and

4. Translational Tumor Immunology, The Wistar Institute, Philadelphia, PA

Abstract

Key Points This study demonstrated an essential role of COX-1 in early B-cell development. Low-dose aspirin may have a potential suppressive effect on B-cell development in humans.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/10/1610/1379675/1610.pdf

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