An enhanced International Prognostic Index (NCCN-IPI) for patients with diffuse large B-cell lymphoma treated in the rituximab era

Author:

Zhou Zheng1,Sehn Laurie H.2,Rademaker Alfred W.1,Gordon Leo I.1,LaCasce Ann S.3,Crosby-Thompson Allison3,Vanderplas Ann4,Zelenetz Andrew D.5,Abel Gregory A.3,Rodriguez Maria A.6,Nademanee Auayporn7,Kaminski Mark S.8,Czuczman Myron S.9,Millenson Michael10,Niland Joyce4,Gascoyne Randy D.2,Connors Joseph M.2,Friedberg Jonathan W.11,Winter Jane N.1

Affiliation:

1. Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL;

2. Centre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, BC, Canada;

3. Medical Oncology, Dana-Farber Cancer Institute, Boston, MA;

4. Biostatistics and Data Coordinating Center, City of Hope National Medical Center, Duarte, CA;

5. Medicine/Lymphoma, Memorial Sloan-Kettering Cancer Center, New York, NY;

6. Lymphoma/Myeloma, University of Texas MD Anderson Cancer Center, Houston, TX;

7. Hematology and Stem Cell Transplantation, City of Hope National Medical Center, Duarte, CA;

8. University of Michigan Comprehensive Cancer Center, Ann Arbor, MI;

9. Departments of Medicine and Immunology, Roswell Park Cancer Institute, Buffalo, NY;

10. Fox Chase Cancer Center, Philadelphia, PA; and

11. James P. Wilmot Cancer Center, University of Rochester, Rochester, NY

Abstract

Key Points The clinically based NCCN-IPI is a robust prognostic tool for the rituximab era that better discriminates low- and high-risk DLBCL patients compared with the IPI. The NCCN-IPI outperforms the IPI by refined categorization of age and LDH, and the identification of disease involvement at specific extranodal sites.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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