Nontoxic polyphosphate inhibitors reduce thrombosis while sparing hemostasis-Reference-Cited by-同舟云学术

Nontoxic polyphosphate inhibitors reduce thrombosis while sparing hemostasis

Published:2014-11-20 Issue:22 Volume:124 Page:3183-3190
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Travers Richard J.¹,Shenoi Rajesh A.²,Kalathottukaren Manu Thomas²,Kizhakkedathu Jayachandran N.²³,Morrissey James H.¹^ORCID

Affiliation:

1. Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL; and

2. Centre for Blood Research and Department of Pathology and Laboratory Medicine, and

3. Department of Chemistry, University of British Columbia, Vancouver, BC, Canada

Abstract

Key Points Polyphosphate inhibitors are antithrombotics with a novel mechanism of action and reduced bleeding side effects compared with heparin. Originally identified polyphosphate inhibitors were all toxic; this study reports the development of safe and effective alternatives.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/22/3183/1465044/3183.pdf

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4. Polyphosphate: an ancient molecule that links platelets, coagulation, and inflammation.;Morrissey;Blood,2012

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