In vitro evidence of a tissue factor-independent mode of action of recombinant factor VIIa in hemophilia-Reference-Cited by-同舟云学术

In vitro evidence of a tissue factor-independent mode of action of recombinant factor VIIa in hemophilia

Published:2014-11-13 Issue:20 Volume:124 Page:3172-3174
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Augustsson Cecilia¹,Persson Egon¹

Affiliation:

1. Haemophilia Biology, Novo Nordisk A/S, Måløv, Denmark

Abstract

Key Points The negative impact on thrombin generation of zymogen FVII competing with rFVIIa for TF is counteracted by FVII (auto)activation. Correction of hemophilia A occurs in a rFVIIa concentration range where detectable effects of FVII competition are minimal or absent.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/20/3172/1381669/3172.pdf

Reference17 articles.

1. The use of recombinant factor VIIa in the treatment of bleeding disorders.;Roberts;Blood,2004

2. Inhibition of thrombin generation by the zymogen factor VII: implications for the treatment of hemophilia A by factor VIIa.;van ’t Veer;Blood,2000

3. Mechanism of factor VIIa-dependent coagulation in hemophilia blood.;Butenas;Blood,2002

4. Platelet-dependent action of high-dose factor VIIa.;Hoffman;Blood,2002

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