Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia

Author:

Rajasagi Mohini12,Shukla Sachet A.13,Fritsch Edward F.13,Keskin Derin B.12,DeLuca David13,Carmona Ellese4,Zhang Wandi12,Sougnez Carrie3,Cibulskis Kristian3,Sidney John5,Stevenson Kristen6,Ritz Jerome127,Neuberg Donna6,Brusic Vladimir1,Gabriel Stacey3,Lander Eric S.3,Getz Gad38,Hacohen Nir39,Wu Catherine J.127

Affiliation:

1. Cancer Vaccine Center and

2. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA;

3. Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA;

4. Division of Medical Sciences: Biological and Biomedical Sciences, Harvard Medical School, Boston, MA;

5. La Jolla Institute for Allergy and Immunology, La Jolla, CA;

6. Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA;

7. Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA;

8. Massachusetts General Hospital Cancer Center and Department of Pathology, Massachusetts General Hospital, Boston, MA; and

9. The Division of Allergy, Immunology, and Rheumatology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA

Abstract

Key Points Tumor neoantigens are a promising class of immunogens based on exquisite tumor specificity and the lack of central tolerance against them. Massively parallel DNA sequencing with class I prediction enables systematic identification of tumor neoepitopes (including from CLL).

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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