Laboratory predictors of bleeding and the effect of platelet and RBC transfusions on bleeding outcomes in the PLADO trial-Reference-Cited by-同舟云学术

Laboratory predictors of bleeding and the effect of platelet and RBC transfusions on bleeding outcomes in the PLADO trial

Published:2017-09-07 Issue:10 Volume:130 Page:1247-1258
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Uhl Lynne¹²,Assmann Susan F.³,Hamza Taye H.³,Harrison Ryan W.⁴,Gernsheimer Terry⁵⁶⁷,Slichter Sherrill J.⁵⁶⁷

Affiliation:

1. Harvard Medical School, Boston, MA;

2. Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA;

3. New England Research Institutes, Watertown, MA;

4. Corrona LLC, Southborough, MA;

5. Division of Hematology, University of Washington School of Medicine, Seattle, WA;

6. Seattle Cancer Care Alliance, Seattle, WA; and

7. Bloodworks Northwest, Seattle, WA

Abstract

Key Points Laboratory parameters associated with increased bleeding were platelet counts ≤5 × 109/L, hematocrits ≤25%, INR >1.2, and aPTT >30 seconds. Platelet and RBC transfusions on days with bleeding are often not sufficient to change bleeding outcomes on the following day.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/130/10/1247/1402001/blood757930.pdf

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