Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells-Reference-Cited by-同舟云学术

Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells

Published:2016-03-03 Issue:9 Volume:127 Page:1138-1150
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Cea Michele¹²^ORCID,Cagnetta Antonia¹²^ORCID,Adamia Sophia¹,Acharya Chirag¹,Tai Yu-Tzu¹,Fulciniti Mariateresa¹,Ohguchi Hiroto¹,Munshi Aditya¹,Acharya Prakrati¹,Bhasin Manoj K.³,Zhong Lei⁴,Carrasco Ruben¹,Monacelli Fiammetta²,Ballestrero Alberto²,Richardson Paul¹,Gobbi Marco²,Lemoli Roberto M.²,Munshi Nikhil¹,Hideshima Teru¹,Nencioni Alessio²,Chauhan Dharminder¹,Anderson Kenneth C.¹

Affiliation:

1. LeBow Institute for Myeloma Therapeutics and Jerome Lipper Center for Multiple Myeloma Research, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA;

2. Clinic of Hematology, Department of Internal Medicine, University of Genoa, Istituto di Ricovero e Cura a Carattere Scientifico Scientifico Azienda Ospedaliera Universitaria San Martino–Istituto Scientifico Tumori, Genoa, Italy;

3. Beth Israel Deaconess Medical Center Genomics, Proteomics, Bioinformatics and Systems Biology Center, Beth Israel Deaconess Medical Center, Boston, MA; and

4. The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA

Abstract

Key Points SIRT6 is highly expressed in multiple myeloma cells and blocks expression of ERK-regulated genes. Targeting SIRT6 enzymatic activity sensitizes multiple myeloma cells to DNA-damaging agents.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/9/1138/1395521/1138.pdf

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