Prophylactic transfusion for pregnant women with sickle cell disease: a systematic review and meta-analysis

Author:

Malinowski Ann Kinga12,Shehata Nadine23456,D’Souza Rohan12,Kuo Kevin H. M.25,Ward Richard25,Shah Prakesh S.237,Murphy Kellie12

Affiliation:

1. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynaecology, Mount Sinai Hospital, Toronto, Canada;

2. Department of Medicine and

3. Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Canada;

4. Division of Haematology, Department of Medicine, Mount Sinai Hospital, Toronto, Canada;

5. Division of Medical Oncology and Haematology, Department of Medicine, University Health Network, Toronto, Canada; and

6. Department of Laboratory Medicine and Pathobiology, and

7. Department of Paediatrics, Mount Sinai Hospital, Toronto, Canada

Abstract

Key Points Prophylactic transfusion in pregnant women with SCD may reduce maternal mortality, vaso-occlusive pain events, and pulmonary complications. Prophylactic transfusion in pregnant women with SCD may similarly reduce perinatal mortality, neonatal death, and preterm birth.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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