Detailed characterization of multiple myeloma circulating tumor cells shows unique phenotypic, cytogenetic, functional, and circadian distribution profile-Reference-Cited by-同舟云学术

Detailed characterization of multiple myeloma circulating tumor cells shows unique phenotypic, cytogenetic, functional, and circadian distribution profile

Published:2013-11-21 Issue:22 Volume:122 Page:3591-3598
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Paiva Bruno¹,Paino Teresa²,Sayagues Jose-Maria²³,Garayoa Mercedes²,San-Segundo Laura²,Martín Montserrat²,Mota Ines³,Sanchez María-Luz²³,Bárcena Paloma²³,Aires-Mejia Irene²,Corchete Luis²,Jimenez Cristina²,Garcia-Sanz Ramon²,Gutierrez Norma C.²,Ocio Enrique M.²,Mateos Maria-Victoria²,Vidriales Maria-Belen²,Orfao Alberto²³,San Miguel Jesús F.¹

Affiliation:

1. Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada, Pamplona, Spain;

2. Hospital Universitario de Salamanca, Instituto de Investigaion Biomedica de Salamanca, Instituto de Biologia Molecular y Celular del Cancer (Univesidad de Salamanca - Consejo Superior de Investigaciones Cientificas), Salamanca, Spain; and

3. Servicio General de Citometría and Departamento de Medicina, Universidad de Salamanca, Salamanca, Spain

Abstract

Key Points Detailed characterization of myeloma circulating tumor cells shows that these represent a unique subpopulation of BM clonal PCs. Myeloma CTCs are clonogenic, quiescent, and may represent an ancestral clone potentially driven by circadian rhythms.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/22/3591/1371749/3591.pdf

Reference50 articles.

1. A monoclonal gammopathy precedes multiple myeloma in most patients.;Weiss;Blood,2009

2. Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: a prospective study.;Landgren;Blood,2009

3. Consensus recommendations for standard investigative workup: report of the International Myeloma Workshop Consensus Panel 3.;Dimopoulos;Blood,2011

4. Soft-tissue plasmacytomas in multiple myeloma: incidence, mechanisms of extramedullary spread, and treatment approach.;Bladé;J Clin Oncol,2011

5. Plasma cell leukemia: consensus statement on diagnostic requirements, response criteria and treatment recommendations by the International Myeloma Working Group.;Fernández de Larrea;Leukemia,2013

Cited by 138 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Circulating Multiple Myeloma Cells (CMMCs) as Prognostic and Predictive Markers in Multiple Myeloma and Smouldering MM Patients;Cancers;2024-08-23

2. Low circulating tumor cell levels correlate with favorable outcomes and distinct biological features in multiple myeloma;American Journal of Hematology;2024-06-11

3. Liquid Biopsies as Non-Invasive Tools for Mutation Profiling in Multiple Myeloma: Application Potential, Challenges, and Opportunities;International Journal of Molecular Sciences;2024-05-10

4. Circadian regulation of cancer stem cells and the tumor microenvironment during metastasis;Nature Cancer;2024-04-23

5. Circulating plasma cells as a predictive biomarker in Multiple myeloma: an updated systematic review and meta-analysis;Annals of Medicine;2024-04-10