Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans-Reference-Cited by-同舟云学术

Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans

Published:2014-06-19 Issue:25 Volume:123 Page:3988-3998
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Flynn Ryan¹,Du Jing¹,Veenstra Rachelle G.¹,Reichenbach Dawn K.¹,Panoskaltsis-Mortari Angela¹,Taylor Patricia A.¹,Freeman Gordon J.²,Serody Jonathan S.³,Murphy William J.⁴,Munn David H.⁵,Sarantopoulos Stefanie³,Luznik Leo⁶,Maillard Ivan⁷,Koreth John²,Cutler Corey²,Soiffer Robert J.²,Antin Joseph H.²,Ritz Jerome²,Dubovsky Jason A.⁸,Byrd John C.⁸,MacDonald Kelli P.⁹,Hill Geoff R.⁹,Blazar Bruce R.¹

Affiliation:

1. Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN;

2. Dana-Farber Cancer Institute, Boston, MA;

3. Lineberger Comprehensive Cancer Center, Division of Hematology/Oncology, University of North Carolina, Chapel Hill, NC;

4. Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA;

5. Department of Pediatrics, Georgia Health Sciences University, Augusta, GA;

6. Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, The Johns Hopkins University, Baltimore, MD;

7. Life Sciences Institute and Department of Internal Medicine, Division of Hematology-Oncology, University of Michigan, Ann Arbor, MI;

8. Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH; and

9. Department of Immunology, Queensland Institute of Medical Research, Brisbane, Australia

Abstract

Key Points T follicular helper cells and germinal center B cells are increased and strongly correlate with the development of cGVHD in a murine model. Blocking mAbs for IL-21, ICOS, and CD40L are potential novel therapeutics for cGVHD.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/25/3988/1464808/3988.pdf

Reference35 articles.

1. Chronic graft-versus-host disease following umbilical cord blood transplantation: retrospective survey involving 1072 patients in Japan.;Narimatsu;Blood,2008

2. Umbilical cord blood transplantation after nonmyeloablative conditioning: impact on transplantation outcomes in 110 adults with hematologic disease.;Brunstein;Blood,2007

3. Chronic graft-versus-host disease: implications of the National Institutes of Health consensus development project on criteria for clinical trials.;Pavletic;Bone Marrow Transplant,2006

4. Transplantation’s greatest challenges: advances in chronic graft-versus-host disease.;Shlomchik;Biol Blood Marrow Transplant,2007

5. Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans.;Srinivasan;Blood,2012

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