Splenic TFH expansion participates in B-cell differentiation and antiplatelet-antibody production during immune thrombocytopenia-Reference-Cited by-同舟云学术

Splenic TFH expansion participates in B-cell differentiation and antiplatelet-antibody production during immune thrombocytopenia

Published:2014-10-30 Issue:18 Volume:124 Page:2858-2866
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Audia Sylvain¹²³,Rossato Marzia¹,Santegoets Kim¹,Spijkers Sanne¹,Wichers Catharina¹,Bekker Cornelis¹,Bloem Andries¹,Boon Louis⁴,Flinsenberg Thijs¹,Compeer Ewoud¹,van den Broek Theo¹,Facy Olivier⁵,Ortega-Deballon Pablo⁵,Berthier Sabine³,Leguy-Seguin Vanessa³,Martin Laurent²⁶,Ciudad Marion²,Samson Maxime²,Trad Malika²,Lorcerie Bernard³,Janikashvili Nona²,Saas Philippe²,Bonnotte Bernard²³,Radstake Timothy R. D. J.¹

Affiliation:

1. Laboratory of Translational Immunology, University Medical Center, Utrecht, The Netherlands;

2. Centre de Recherche INSERM 1098, University of Bourgogne/Franche-Comté, Fédération Hospitalo-Universitaire Integrated Center for Research in Inflammatory Diseases, Bourgogne, France;

3. Department of Internal Medicine and Clinical Immunology, Competence Center for Autoimmune Cytopenia, University Hospital, Dijon, France;

4. Bioceros, Utrecht, The Netherlands; and

5. Department of Surgery and

6. Department of Pathology, University Hospital, Dijon, France

Abstract

Key Points Human splenic TFH expansion during ITP participates in B-cell differentiation and antiplatelet-antibody production. IL-21 and CD40 are key TFH molecules that could be promising targets in the treatment of ITP.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/18/2858/1381065/2858.pdf

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