STAT3 mutations indicate the presence of subclinical T-cell clones in a subset of aplastic anemia and myelodysplastic syndrome patients-Reference-Cited by-同舟云学术

STAT3 mutations indicate the presence of subclinical T-cell clones in a subset of aplastic anemia and myelodysplastic syndrome patients

Published:2013-10-03 Issue:14 Volume:122 Page:2453-2459
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Jerez Andres¹,Clemente Michael J.¹,Makishima Hideki¹,Rajala Hanna²,Gómez-Seguí Ines¹,Olson Thomas³,McGraw Kathy⁴,Przychodzen Bartlomiej¹,Kulasekararaj Austin⁵,Afable Manuel¹,Husseinzadeh Holleh D.¹,Hosono Naoko¹,LeBlanc Francis³,Lagström Sonja⁶,Zhang Dan³,Ellonen Pekka⁶,Tichelli André⁷,Nissen Catherine⁷,Lichtin Alan E.¹,Wodnar-Filipowicz Aleksandra⁷,Mufti Ghulam J.⁵,List Alan F.⁴,Mustjoki Satu²,Loughran Thomas P.³,Maciejewski Jaroslaw P.¹

Affiliation:

1. Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH;

2. Hematology Research Unit, Department of Medicine, Division of Hematology, Helsinki University Central Hospital, Helsinki, Finland;

3. Penn State Hershey Cancer Institute, Penn State Hershey College of Medicine, Hershey, PA;

4. H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL;

5. Department of Haematological Medicine, King's College London School of Medicine, London, United Kingdom;

6. Institute of Molecular Medicine Finland, University of Helsinki, Helsinki, Finland; and

7. Clinical and Experimental Hematology, University Hospital Basel, Basel, Switzerland

Abstract

Key PointsSTAT3+ T cells are found not only in detected concomitant LGL-BMFs, but in cases in which an LGL expansion was not suspected. Transformation via acquisition of a somatic mutation in T cells may be a mechanism of immune, mainly hypoplastic, bone marrow failure.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/14/2453/1370056/2453.pdf

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