A capture-sequencing strategy identifies IRF8, EBF1, and APRIL as novel IGH fusion partners in B-cell lymphoma-Reference-Cited by-同舟云学术

A capture-sequencing strategy identifies IRF8, EBF1, and APRIL as novel IGH fusion partners in B-cell lymphoma

Published:2013-08-01 Issue:5 Volume:122 Page:726-733
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Bouamar Hakim¹,Abbas Saman¹,Lin An-Ping¹,Wang Long¹,Jiang Daifeng¹,Holder Kenneth N.²,Kinney Marsha C.²,Hunicke-Smith Scott³,Aguiar Ricardo C. T.¹⁴⁵

Affiliation:

1. Division of Hematology and Medical Oncology, Department of Medicine, and

2. Department of Pathology, University of Texas Health Science Center, San Antonio, TX;

3. Center for Systems and Synthetic Biology, University of Texas, Austin, TX; and

4. Cancer Therapy and Research Center, and

5. Greehey Children's Cancer Research Institute, University of Texas Health Sciences Center, San Antonio, TX

Abstract

Key Points Targeted capture/next-generation sequencing is a powerful tool for the diagnosis of known and discovery of new IGH fusions in DLBCL. IGH-mediated deregulation of IRF8 and EBF1 in DLBCL is characterized by induction of AID and BCL6, suppression of PRDM1, and antiapoptosis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/5/726/1373451/726.pdf

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