Nonclassical FCGR2C haplotype is associated with protection from red blood cell alloimmunization in sickle cell disease

Author:

Meinderts Sanne M.1,Sins Joep W. R.23,Fijnvandraat Karin24,Nagelkerke Sietse Q.12,Geissler Judy1,Tanck Michael W.5,Bruggeman Christine1,Biemond Bart J.3,Rijneveld Anita W.6,Kerkhoffs Jean-Louis H.7,Pakdaman Sadaf8,Habibi Anoosha9,van Bruggen Robin1,Kuijpers Taco W.12,Pirenne France8,van den Berg Timo K.110

Affiliation:

1. Department of Blood Cell Research, Sanquin Research, and Landsteiner Laboratory,

2. Department of Pediatric Hematology, Immunology, and Infectious Diseases, Emma Children’s Hospital, and

3. Department of Hematology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands;

4. Department of Plasma Proteins, Sanquin Research, Amsterdam, The Netherlands;

5. Department of Clinical Epidemiology, Biostatistics, and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands;

6. Department of Hematology, Erasmus Medical Center, University Medical Center, Rotterdam, The Netherlands;

7. Department of Hematology, Haga Hospital, The Hague, The Netherlands;

8. Etablissement Français Du Sang Ile de France, INSERM U955, University of Paris Est-Créteil, and

9. Reference Center for Sickle Cell Disease, Hôpital Henri Mondor, Créteil, France; and

10. Department of Molecular Cell Biology, Vrije University Medical Center, Amsterdam, The Netherlands

Abstract

Key Points Variation in the Fcγ receptor gene cluster is associated with protection from RBC alloimmunization in patients with SCD. This association appears to be strongest for alloimmunization to antigens other than the immunogenic Rh or K.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Cited by 34 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3