SF3B1-initiating mutations in MDS-RSs target lymphomyeloid hematopoietic stem cells-Reference-Cited by-同舟云学术

SF3B1-initiating mutations in MDS-RSs target lymphomyeloid hematopoietic stem cells

Published:2017-08-17 Issue:7 Volume:130 Page:881-890
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Mortera-Blanco Teresa¹,Dimitriou Marios¹,Woll Petter S.¹²,Karimi Mohsen¹,Elvarsdottir Edda¹,Conte Simona¹,Tobiasson Magnus¹,Jansson Monika¹,Douagi Iyadh¹,Moarii Matahi³,Saft Leonie⁴,Papaemmanuil Elli³,Jacobsen Sten Eirik W.¹²,Hellström-Lindberg Eva¹

Affiliation:

1. Center for Hematology and Regenerative Medicine, Karolinska Institutet, Department of Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden;

2. Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom;

3. Memorial Sloan Kettering Cancer Center, New York, NY; and

4. Division of Hematopathology, Department of Pathology, Karolinska University Hospital, Solna, Sweden

Abstract

Key Points SF3B1 mutations in MDS-RS have a multipotent lymphomyeloid origin. Transplantation of SF3B1 mutated MDS-RS HSCs into immune-deficient mice results in generation of characteristic ring sideroblasts.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/130/7/881/1367491/blood776070.pdf

Reference43 articles.

1. Significance of JAK2 and TET2 mutations in myelodysplastic syndromes;Hellström-Lindberg;Blood Rev,2010

2. Frequent pathway mutations of splicing machinery in myelodysplasia;Yoshida;Nature,2011

3. Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts;Papaemmanuil;N Engl J Med,2011

4. Mutation in TET2 in myeloid cancers;Delhommeau;N Engl J Med,2009

5. Clinical and biological implications of driver mutations in myelodysplastic syndromes;Papaemmanuil;Blood,2013

Cited by 57 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. SF3B1-mutant mis-splicing ofUBA1confers a targetable therapeutic vulnerability through UBA1 inhibition;2024-08-28

2. Mis-splicing of Mitotic Regulators Sensitizes SF3B1-Mutated Human HSCs to CHK1 Inhibition;Blood Cancer Discovery;2024-06-07

3. Competition of dual SF3B1mt clones in MDS-RS is associated with distinct RNA mis-splicing in hematopoietic stem cells;Blood Neoplasia;2024-06

4. Understanding iron homeostasis in MDS: the role of erythroferrone;Frontiers in Oncology;2024-05-21

5. Mutations in the splicing factor SF3B1 are linked to frequent emergence of HLA-DRlow/neg monocytes in lower-risk myelodysplastic neoplasms;Leukemia;2024-04-17