Mutations of MAP2K1 are frequent in pediatric-type follicular lymphoma and result in ERK pathway activation-Reference-Cited by-同舟云学术

Mutations of MAP2K1 are frequent in pediatric-type follicular lymphoma and result in ERK pathway activation

Published:2017-07-20 Issue:3 Volume:130 Page:323-327
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Schmidt Janine¹,Ramis-Zaldivar Joan Enric²^ORCID,Nadeu Ferran²^ORCID,Gonzalez-Farre Blanca²^ORCID,Navarro Alba²^ORCID,Egan Caoimhe³,Montes-Mojarro Ivonne Aidee¹,Marafioti Teresa⁴,Cabeçadas Jose⁵,van der Walt Jon⁶,Dojcinov Stefan⁷,Rosenwald Andreas⁸⁹,Ott German¹⁰¹¹,Bonzheim Irina¹,Fend Falko¹,Campo Elias²^ORCID,Jaffe Elaine S.³,Salaverria Itziar²^ORCID,Quintanilla-Martinez Leticia¹^ORCID

Affiliation:

1. Institute of Pathology and Neuropathology, Eberhard Karls University of Tübingen and Comprehensive Cancer Center, Tübingen University Hospital, Tübingen, Germany;

2. Hematopathology Unit, Hospital Clinic, Institut d’Investigacions Biomèdiques August Pi Sunyer, Centro de Investigación Biomédica en Red de Cáncer, Barcelona, Spain;

3. Hematopathology Section, Laboratory of Pathology, National Cancer Institute, Bethesda, MD;

4. Department of Cellular Pathology, Barts and The London National Health Service Trust, London, United Kingdom;

5. Pathology Department, Instituto Portugues de Oncología, Lisbon, Portugal;

6. Department of Histopathology, Guy's and St Thomas’ Hospitals, London, United Kingdom;

7. Department of Pathology, All Wales Lymphoma Panel, University Hospital of Wales, Cardiff, United Kingdom;

8. Institute of Pathology, University of Würzburg, Würzburg, Germany;

9. Comprehensive Cancer Center Mainfranken, Würzburg, Germany;

10. Department of Clinical Pathology, Robert Bosch Hospital, Stuttgart, Germany; and

11. Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany

Abstract

Key Points TNFRSF14 and MAP2K1 mutations are frequent in PTFL but do not occur together in the majority of cases. MAP2K1 mutations lead to activation of the downstream target phosphorylated extracellular signal-regulated kinase.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/130/3/323/1404929/blood776278.pdf

Reference25 articles.

1. Indolent lymphomas in the pediatric population: follicular lymphoma, IRF4/MUM1+ lymphoma, nodal marginal zone lymphoma and chronic lymphocytic leukemia;Quintanilla-Martinez;Virchows Arch,2016

2. The 2016 revision of the World Health Organization classification of lymphoid neoplasms;Swerdlow;Blood,2016

3. Pediatric-type nodal follicular lymphoma: a biologically distinct lymphoma with frequent MAPK pathway mutations;Louissaint;Blood,2016

4. A study of the mutational landscape of pediatric-type follicular lymphoma and pediatric nodal marginal zone lymphoma;Ozawa;Mod Pathol,2016

5. Genome-wide analysis of pediatric-type follicular lymphoma reveals low genetic complexity and recurrent alterations of TNFRSF14 gene;Schmidt;Blood,2016

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