Targeting acute myeloid leukemia with a small molecule inhibitor of the Myb/p300 interaction

Author:

Uttarkar Sagar12,Dassé Emilie3,Coulibaly Anna1,Steinmann Simone1,Jakobs Anke1,Schomburg Caroline4,Trentmann Amke1,Jose Joachim5,Schlenke Peter6,Berdel Wolfgang E.7,Schmidt Thomas J.4,Müller-Tidow Carsten8,Frampton Jon3,Klempnauer Karl-Heinz1

Affiliation:

1. Institute for Biochemistry and

2. Graduate School of Chemistry, University of Münster, Münster, Germany;

3. Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom;

4. Institute for Pharmaceutical Biology and Phytochemistry and

5. Institute for Pharmaceutical and Medicinal Chemistry, University of Münster, Münster, Germany;

6. Institute for Transfusion Medicine, University Hospital, University of Graz, Graz, Austria;

7. Department of Medicine A, Hematology and Oncology, University Hospital, University of Münster, Münster, Germany; and

8. Department of Medicine, Hematology and Oncology, University of Halle, Halle, Germany

Abstract

Key Points Inhibition of Myb activity by a small molecule blocks proliferation of AML cells and prolongs survival of mice in an in vivo AML model.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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