Clonal evolution leading to ibrutinib resistance in chronic lymphocytic leukemia

Author:

Ahn Inhye E.1,Underbayev Chingiz2,Albitar Adam3,Herman Sarah E. M.2,Tian Xin4,Maric Irina5,Arthur Diane C.6,Wake Laura6,Pittaluga Stefania6,Yuan Constance M.6,Stetler-Stevenson Maryalice6,Soto Susan2,Valdez Janet2,Nierman Pia2,Lotter Jennifer2,Xi Liqiang6,Raffeld Mark6,Farooqui Mohammed2,Albitar Maher3,Wiestner Adrian2

Affiliation:

1. Medical Oncology Service, National Cancer Institute, and

2. Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD;

3. NeoGenomics Laboratories, Irvine, CA; and

4. Office of Biostatistics Research, National Heart, Lung, and Blood Institute,

5. Department of Laboratory Medicine, Clinical Center, and

6. Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD

Abstract

Key Points Most cases of ibrutinib-resistant CLL were due to mutations in BTK and/or PLCG2 and often composed of multiple independent subclones. High sensitivity testing identified resistance mutations up to 15 months before manifestation of clinical progression.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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