Clarifying immunoglobulin gene usage in systemic and localized immunoglobulin light-chain amyloidosis by mass spectrometry-Reference-Cited by-同舟云学术

Clarifying immunoglobulin gene usage in systemic and localized immunoglobulin light-chain amyloidosis by mass spectrometry

Published:2017-01-19 Issue:3 Volume:129 Page:299-306
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Kourelis Taxiarchis V.¹,Dasari Surendra²,Theis Jason D.³,Ramirez-Alvarado Marina⁴,Kurtin Paul J.³,Gertz Morie A.¹,Zeldenrust Steven R.¹,Zenka Roman M.⁵,Dogan Ahmet⁶,Dispenzieri Angela¹

Affiliation:

1. Division of Hematology, Department of Medicine,

2. Department of Health Sciences Research,

3. Department of Laboratory Medicine and Pathology,

4. Department of Biochemistry and Molecular Biology, and

5. Division of information Management and Analytics, Mayo Clinic, Rochester, MN; and

6. Department of Laboratory Medicine and Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY

Abstract

Key Points Mass spectrometry is a high-throughput, low-resource technique that can identify immunoglobulin variable region gene from tissue specimens. IGVL gene usage is restricted and different between systemic and localized AL and only partially explains organ tropism in this disease.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/3/299/1401192/blood743997.pdf

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