Alteration of blood clotting and lung damage by protamine are avoided using the heparin and polyphosphate inhibitor UHRA-Reference-Cited by-同舟云学术

Alteration of blood clotting and lung damage by protamine are avoided using the heparin and polyphosphate inhibitor UHRA

Published:2017-03-09 Issue:10 Volume:129 Page:1368-1379
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Kalathottukaren Manu Thomas¹²^ORCID,Abraham Libin³,Kapopara Piyushkumar R.¹⁴,Lai Benjamin F. L.¹²,Shenoi Rajesh A.¹²,Rosell Federico I.¹,Conway Edward M.¹⁴,Pryzdial Edward L. G.¹²⁵,Morrissey James H.⁶^ORCID,Haynes Charles A.¹⁷,Kizhakkedathu Jayachandran N.¹²⁸^ORCID

Affiliation:

1. Centre for Blood Research,

2. Department of Pathology and Laboratory Medicine,

3. Department of Microbiology and Immunology, and

4. Department of Medicine, University of British Columbia, Vancouver, BC, Canada;

5. Centre for Innovation, Canadian Blood Services, Vancouver, BC, Canada;

6. Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL; and

7. Michael Smith Laboratories, Department of Chemical and Biological Engineering, and

8. Department of Chemistry, University of British Columbia, Vancouver, BC, Canada

Abstract

Key Points Protamine, the clinically used heparin antidote, alters clot structure by direct incorporation, explaining its known adverse effects. UHRA, a heparin antidote, neutralizes heparin anticoagulation without affecting clotting, clot structure, or lung damage in mice.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/10/1368/1399086/blood747915.pdf

Reference46 articles.

1. Thrombosis: a major contributor to global disease burden;Raskob;Semin Thromb Hemost,2014

2. Bleeding risk and the management of bleeding complications in patients undergoing anticoagulant therapy: focus on new anticoagulant agents;Crowther;Blood,2008

3. Extracellular RNA constitutes a natural procoagulant cofactor in blood coagulation;Kannemeier;Proc Natl Acad Sci USA,2007

4. Polyphosphate modulates blood coagulation and fibrinolysis;Smith;Proc Natl Acad Sci USA,2006

5. Extracellular DNA traps promote thrombosis;Fuchs;Proc Natl Acad Sci USA,2010

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