Role for early-differentiated natural killer cells in infectious mononucleosis

Author:

Azzi Tarik12,Lünemann Anna12,Murer Anita3,Ueda Seigo124,Béziat Vivien5,Malmberg Karl-Johan567,Staubli Georg28,Gysin Claudine29,Berger Christoph12,Münz Christian3,Chijioke Obinna310,Nadal David12

Affiliation:

1. Division of Infectious Diseases and Hospital Epidemiology and

2. Children’s Research Center, University Children’s Hospital of Zurich, Zurich, Switzerland;

3. Viral Immunobiology, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland;

4. Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical University, Asahikawa, Japan;

5. Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Solna, Sweden;

6. Institute for Cancer Research, Oslo University Hospital, Oslo, Norway;

7. Institute of Clinical Medicine, University of Oslo, Oslo, Norway;

8. Emergency Department and

9. Division of Otolaryngology, University Children’s Hospital of Zurich, Zurich, Switzerland; and

10. Institute of Surgical Pathology, University Hospital Zurich, University of Zurich, Zurich, Switzerland

Abstract

Key Points Early-differentiated NK cells accumulate and proliferate during IM. These early-differentiated NK cells preferentially target lytic EBV-infected B cells in vitro.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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