Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy

Author:

Hsieh Yao-Te1,Gang Eun Ji1,Geng Huimin2,Park Eugene1,Huantes Sandra1,Chudziak Doreen3,Dauber Katrin3,Schaefer Paul1,Scharman Carlton1,Shimada Hiroyuki4,Shojaee Seyedmehdi2,Klemm Lars2,Parameswaran Reshmi1,Loh Mignon5,Kang Eun-Suk6,Koo Hong Hoe7,Hofmann Wolf-Karsten8,Andrade Jacob9,Crooks Gay M.9,Willman Cheryl L.10,Müschen Markus2,Papayannopoulou Thalia11,Heisterkamp Nora1,Bönig Halvard311,Kim Yong-Mi1

Affiliation:

1. Department of Pediatrics, Division of Hematology and Oncology, Children’s Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA;

2. Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA;

3. German Red Cross Blood Service and Institute for Transfusion Medicine and Immunohematology, Goethe University, Frankfurt, Germany;

4. Department of Pathology and Laboratory Medicine, Children’s Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA;

5. Department of Pediatrics, University of California San Francisco, San Francisco, CA;

6. Department of Laboratory Medicine and Genetics and

7. Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea;

8. Department of Hematology and Oncology, University Hospital Mannheim, Mannheim, Germany;

9. Department of Pathology & Laboratory Medicine, University of California Los Angeles, Los Angeles, CA;

10. University of New Mexico Cancer Center and Departments of Pathology, Internal Medicine, Mathematics and Statistics, and Physics and Astronomy, University of New Mexico, Albuquerque, NM; and

11. Department of Medicine/Hematology, University of Washington, Seattle, WA

Abstract

Key Points We evaluated interference with integrin alpha4–mediated stromal adhesion as a new acute lymphoblastic leukemia treatment. Integrin alpha4 blockade using natalizumab in combination with chemotherapy sensitizes pre-B acute lymphoblastic leukemia to chemotherapy.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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