Myosin IIa is critical for cAMP-mediated endothelial secretion of von Willebrand factor-Reference-Cited by-同舟云学术

Myosin IIa is critical for cAMP-mediated endothelial secretion of von Willebrand factor

Published:2018-02-08 Issue:6 Volume:131 Page:686-698
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Li Pin¹,Wei Guoqin¹,Cao Yang¹,Deng Qiuping¹,Han Xiaofan¹,Huang Xiaoshuai²,Huo Yingqing¹,He Yulong³,Chen Liangyi²,Luo Jincai¹

Affiliation:

1. Laboratory of Vascular Biology, Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing, China;

2. The State Key Laboratory of Biomembrane and Membrane Biotechnology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking University, Beijing, China; and

3. Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China

Abstract

Key Points Myosin IIa is required for cAMP-mediated endothelial VWF secretion critical for hemostasis and thrombosis. Myosin IIa regulates mature WPB positioning and facilitates WPB exocytosis via zyxin-mediated actin framework formation before fusion.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/131/6/686/1466821/blood802140.pdf

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5. 1-Deamino-8-d-arginine vasopressin: a new pharmacological approach to the management of haemophilia and von Willebrands’ diseases;Mannucci;Lancet,1977

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