Identifying and enriching platelet-producing human stem cell–derived megakaryocytes using factor V uptake-Reference-Cited by-同舟云学术

Identifying and enriching platelet-producing human stem cell–derived megakaryocytes using factor V uptake

Published:2017-07-13 Issue:2 Volume:130 Page:192-204
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Sim Xiuli¹²,Jarocha Danuta³⁴,Hayes Vincent³⁴,Hanby Hayley A.¹⁵⁶,Marks Michael S.⁵⁶,Camire Rodney M.²⁴,French Deborah L.²⁵⁶,Poncz Mortimer³⁴,Gadue Paul²⁵⁶

Affiliation:

1. Department of Cell and Molecular Biology, University of Pennsylvania School of Medicine, Philadelphia, PA;

2. Center for Cellular and Molecular Therapeutics, Children’s Hospital of Philadelphia, Philadelphia, PA;

3. Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA;

4. Department of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, PA;

5. Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA; and

6. Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA

Abstract

Key Points Describe human MK populations representing distinct developmental stages within a heterogeneous culture. FV uptake identifies cultured MKs ready to release platelets upon infusion into mice.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/130/2/192/1403978/blood761049.pdf

Reference81 articles.

1. Platelets generated in vitro from proplatelet-displaying human megakaryocytes are functional;Choi;Blood,1995

2. In vitro megakaryocyte production and platelet biogenesis: state of the art;Reems;Transfus Med Rev,2010

3. Biomanufacture of human platelets for transfusion: Rationale and approaches;Lee;Exp Hematol,2014

4. Ex vivo production of platelets from stem cells;Avanzi;Br J Haematol,2014

5. Ex vivo large-scale generation of human platelets from cord blood CD34+ cells;Matsunaga;Stem Cells,2006

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