Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation-Reference-Cited by-同舟云学术

Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation

Published:2005-03-15 Issue:6 Volume:105 Page:2340-2342
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Mancini Stéphane J. C.¹,Mantei Ned¹,Dumortier Alexis¹,Suter Ueli¹,MacDonald H. Robson¹,Radtke Freddy¹

Affiliation:

1. From the Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges; Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, Zürich, Switzerland.

Abstract

AbstractJagged1-mediated Notch signaling has been suggested to be critically involved in hematopoietic stem cell (HSC) self-renewal. Unexpectedly, we report here that inducible Cre-loxP–mediated inactivation of the Jagged1 gene in bone marrow progenitors and/or bone marrow (BM) stromal cells does not impair HSC self-renewal or differentiation in all blood lineages. Mice with simultaneous inactivation of Jagged1 and Notch1 in the BM compartment survived normally following a 5FU-based in vivo challenge. In addition, Notch1-deficient HSCs were able to reconstitute mice with inactivated Jagged1 in the BM stroma even under competitive conditions. In contrast to earlier reports, these data exclude an essential role for Jagged1-mediated Notch signaling during hematopoiesis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/105/6/2340/1707381/zh800605002340.pdf

Reference18 articles.

1. Kondo M, Wagers AJ, Manz MG, et al. Biology of hematopoietic stem cells and progenitors: implications for clinical application. Annu Rev Immunol.2003;21: 759-806.

2. Radtke F, Wilson A, Mancini SJ, MacDonald HR. Notch regulation of lymphocyte development and function. Nat Immunol.2004;5: 247-253.

3. Stier S, Cheng T, Dombkowski D, Carlesso N, Scadden DT. Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome. Blood. 2002;99: 2369-2378.

4. Varnum-Finney B, Xu L, Brashem-Stein C, et al. Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling. Nat Med.2000;6: 1278-1281.

5. Carlesso N, Aster JC, Sklar J, Scadden DT. Notch1-induced delay of human hematopoietic progenitor cell differentiation is associated with altered cell cycle kinetics. Blood. 1999;93: 838-848.

Cited by 247 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The hematopoietic stem cell expansion niche in fetal liver: Current state of the art and the way forward;Experimental Hematology;2024-08

2. Advances in hematopoietic stem cells ex vivo expansion associated with bone marrow niche;Annals of Hematology;2024-04-30

3. Endothelial Jagged1 levels and distribution are post-transcriptionally controlled by ZFP36 decay proteins;Cell Reports;2024-01

4. Fundamentals and Different Types of Stem Cells;Comprehensive Hematology and Stem Cell Research;2024

5. De novo hematopoiesis from the fetal lung;Blood Advances;2023-11-16