The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in mice that is responsive to therapeutic JAK inhibition-Reference-Cited by-同舟云学术

The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in mice that is responsive to therapeutic JAK inhibition

Published:2013-11-21 Issue:22 Volume:122 Page:3628-3631
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Fleischman Angela G.¹²,Maxson Julia E.¹²,Luty Samuel B.¹²,Agarwal Anupriya¹,Royer Lacey R.¹²,Abel Melissa L.¹²,MacManiman Jason D.¹²,Loriaux Marc M.¹²,Druker Brian J.¹²³,Tyner Jeffrey W.¹²⁴

Affiliation:

1. Division of Hematology & Medical Oncology,

2. Knight Cancer Institute,

3. Howard Hughes Medical Institute, and

4. Department of Cell & Developmental Biology, Oregon Health & Science University, Portland, OR

Abstract

Key Points CSF3R T618I is sufficient to drive a lethal myeloproliferative disease in a mouse bone marrow transplant model. Treatment of CSF3R T618I mice with the JAK1/2 inhibitor ruxolitinib effectively reduces white blood cell count and spleen size.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/22/3628/1372032/3628.pdf

Reference13 articles.

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5. Defective internalization and sustained activation of truncated granulocyte colony-stimulating factor receptor found in severe congenital neutropenia/acute myeloid leukemia.;Ward;Blood,1999

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