Functions of idh1 and its mutation in the regulation of developmental hematopoiesis in zebrafish-Reference-Cited by-同舟云学术

Functions of idh1 and its mutation in the regulation of developmental hematopoiesis in zebrafish

Published:2015-05-07 Issue:19 Volume:125 Page:2974-2984
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Shi Xiangguo¹,He Bai-Liang¹,Ma Alvin C. H.¹,Guo Yuhan¹,Chi Yali²,Man Cheuk Him¹,Zhang Wenqing²,Zhang Yiyue²,Wen Zilong³,Cheng Tao⁴⁵,Leung Anskar Y. H.¹

Affiliation:

1. Division of Haematology, Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China;

2. Department of Cell Biology, Southern Medical University, Guangzhou, China;

3. State Key Laboratory of Molecular Neuroscience, Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China;

4. State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China; and

5. Center for Stem Cell Medicine, Chinese Academy of Medical Sciences, Beijing, China

Abstract

Key Points Zebrafish idh1 plays an important role in the regulation of myelopoiesis and definitive hematopoiesis. Expression of human IDH1-R132H and its zebrafish orthologue induced an increase in myelopoiesis and 2-hydroxyglutrate.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/19/2974/1385206/2974.pdf

Reference46 articles.

1. Recurring mutations found by sequencing an acute myeloid leukemia genome.;Mardis;N Engl J Med,2009

2. Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations.;Gross;J Exp Med,2010

3. Regulation of cancer cell metabolism.;Cairns;Nat Rev Cancer,2011

4. IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication.;Paschka;J Clin Oncol,2010

5. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate.;Ward;Cancer Cell,2010

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