Regulation of ribosomal RNA synthesis in T cells: requirement for GTP and Ebp1-Reference-Cited by-同舟云学术

Regulation of ribosomal RNA synthesis in T cells: requirement for GTP and Ebp1

Published:2015-04-16 Issue:16 Volume:125 Page:2519-2529
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Nguyen Le Xuan Truong¹,Lee Yunqin²,Urbani Lenore¹,Utz Paul J.³,Hamburger Anne W.⁴,Sunwoo John B.²,Mitchell Beverly S.¹

Affiliation:

1. Departments of Medicine and Chemical and Systems Biology, and

2. Department of Otolaryngology (Head and Neck Surgery), Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA;

3. Division of Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford CA; and

4. Department of Pathology and Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD

Abstract

Key Points MPA suppresses ribosomal RNA (rRNA) synthesis and cell proliferation in T cells through TIF-IA, a GTP binding protein. The combination of MPA and sotrastaurin potently suppresses T-cell proliferation and inhibits IL-2 secretion through TIF-IA and ErbB3-binding protein 1 (Ebp1).

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/16/2519/1384852/2519.pdf

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