Idiopathic pneumonia syndrome after hematopoietic cell transplantation: evidence of occult infectious etiologies

Author:

Seo Sachiko1,Renaud Christian2,Kuypers Jane M.13,Chiu Charles Y.4,Huang Meei-Li13,Samayoa Erik4,Xie Hu5,Yu Guixia4,Fisher Cynthia E.16,Gooley Ted A.5,Miller Steven4,Hackman Robert C.137,Myerson David57,Sedlak Ruth H.3,Kim Yae-Jean8,Fukuda Takahiro9,Fredricks David N.16,Madtes David K.56,Jerome Keith R.13,Boeckh Michael156ORCID

Affiliation:

1. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA;

2. Department of Microbiology and Immunology, University of Montreal, Montreal, Canada;

3. Department of Laboratory Medicine, University of Washington, Seattle, WA;

4. Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA;

5. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA;

6. Department of Medicine, and

7. Department of Pathology, University of Washington, Seattle, WA;

8. Department of Pediatrics, Samsung Medical Center, Sungkyungkwan University, School of Medicine, Seoul, Korea; and

9. Hematopoietic Stem Cell Transplantation Division, National Cancer Research Center Hospital, Tokyo, Japan

Abstract

Key Points In patients with previously diagnosed IPS, more than half (57%) had pathogens detected by currently available diagnostic methods. Detection of a pathogen was significantly associated with high mortality regardless of significance of pathogenicity in lung.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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