Fibrin-incorporated vitronectin is involved in platelet adhesion and thrombus formation through homotypic interactions with platelet-associated vitronectin
Author:
Affiliation:
1. From the Departments of Haematology, Medical Oncology, and Immunology, University Medical Centre, Utrecht, the Netherlands; and Department of Nephrology, Leiden University Medical Centre, the Netherlands.
Abstract
Publisher
American Society of Hematology
Subject
Cell Biology,Hematology,Immunology,Biochemistry
Link
http://ashpublications.org/blood/article-pdf/104/4/1034/1700569/zh801604001034.pdf
Reference40 articles.
1. Seiffert D, Schleef RR. Two functionally distinct pools of vitronectin (Vn) in the blood circulation: identification of a heparin-binding competent population of Vn within platelet alpha-granules. Blood. 1996;88: 552-560.
2. Coller BS, Seligsohn U, West SM, Scudder LE, Norton KJ. Platelet fibrinogen and vitronectin in Glanzmann thrombasthenia: evidence consistent with specific roles for glycoprotein IIb/IIIA and alpha v beta 3 integrins in platelet protein trafficking. Blood. 1991;78: 2603-2610.
3. Morgenstern E, Gnad U, Preissner KT, et al. Localization of protein kinase A and vitronectin in resting platelets and their translocation onto fibrin fibers during clot formation. Eur J Cell Biol. 2001;80: 87-98.
4. Tomasini BR, Mosher DF. Vitronectin. Prog Hemost Thromb. 1991;10: 269-305.
5. Hess S, Kanse SM, Kost C, Preissner KT. The versatility of adhesion receptor ligands in haemostasis: morpho-regulatory functions of vitronectin. Thromb Haemost. 1995;74: 258-265.
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