High PD-1 expression and suppressed cytokine signaling distinguish T cells infiltrating follicular lymphoma tumors from peripheral T cells

Author:

Myklebust June H.12,Irish Jonathan M.134,Brody Joshua15,Czerwinski Debra K.1,Houot Roch16,Kohrt Holbrook E.1,Timmerman John7,Said Jonathan8,Green Michael R.1,Delabie Jan9,Kolstad Arne10,Alizadeh Ash A.1,Levy Ronald1

Affiliation:

1. Department of Medicine, Oncology Division, Stanford University, Stanford, CA;

2. Department of Immunology, Institute for Cancer Research, Oslo University Hospital and Centre for Cancer Biomedicine, University of Oslo, Oslo, Norway;

3. Department of Microbiology & Immunology, Baxter Laboratory of Genetic Pharmacology, Stanford University, Stanford, CA;

4. Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN;

5. Lymphoma Immunotherapy Program, Mount Sinai School of Medicine, New York, NY;

6. Service d'Hématologie Clinique, Centre Hospitalier Universitaire de Rennes and Inserm U917, Université de Rennes 1, Rennes, France;

7. Division of Hematology and Oncology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA;

8. Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA;

9. Cancer Clinic, Department of Pathology, Oslo University Hospital, Oslo, Norway; and

10. Cancer Clinic, Department of Oncology, Oslo University Hospital, Oslo, Norway

Abstract

Key Points FL TILs have reduced cytokine signaling.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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