STAT3 supports experimental K-RasG12D–induced murine myeloproliferative neoplasms dependent on serine phosphorylation-Reference-Cited by-同舟云学术

STAT3 supports experimental K-RasG12D–induced murine myeloproliferative neoplasms dependent on serine phosphorylation

Published:2014-10-02 Issue:14 Volume:124 Page:2252-2261
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Gough Daniel J.¹,Marié Isabelle J.¹,Lobry Camille¹,Aifantis Iannis¹,Levy David E.¹

Affiliation:

1. Department of Pathology and NYU Cancer Institute, New York University School of Medicine, New York, NY

Abstract

Key Points Absence of STAT3 serine phosphorylation restricts activated K-Ras–driven myeloproliferative disease in a mouse model. A mitochondrial function of STAT3 supports K-Ras–driven, factor-independent growth of myeloid progenitors in vitro.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/14/2252/1380148/2252.pdf

Reference53 articles.

1. Juvenile myelomonocytic leukemia: a report from the 2nd International JMML Symposium.;Chan;Leuk Res,2009

2. RAS and leukemia: from basic mechanisms to gene-directed therapy.;Beaupre;J Clin Oncol,1999

3. KIT activating mutations: incidence in adult and pediatric acute myeloid leukemia, and identification of an internal tandem duplication.;Beghini;Haematologica,2004

4. Incidence and prognosis of c-KIT and FLT3 mutations in core binding factor (CBF) acute myeloid leukaemias.;Care;Br J Haematol,2003

5. Genetic analysis is consistent with the hypothesis that NF1 limits myeloid cell growth through p21ras.;Kalra;Blood,1994

Cited by 53 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Small molecular inhibitors and degraders targeting STAT3 for cancer therapy: An updated review (from 2022 to 2024);Chinese Chemical Letters;2024-09

2. Structural determinants of mitochondrial STAT3 targeting and function;Mitochondrial Communications;2024-01

3. Recent Progress in Selective COX-2 Inhibitor Formulations and Therapeutic Applications - A Patent Review (2012-2022);Mini-Reviews in Medicinal Chemistry;2023-12

4. A STAT3 protein complex required for mitochondrial mRNA stability and cancer;Cell Reports;2023-09

5. STAT proteins in cancer: orchestration of metabolism;Nature Reviews Cancer;2023-01-03