A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells-Reference-Cited by-同舟云学术

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A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells

Published:2013-12-12 Issue:25 Volume:122 Page:4086-4089
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Kim Soo Jin¹,Zhao Hongbo¹,Hardikar Swanand¹,Singh Anup Kumar¹,Goodell Margaret A.²,Chen Taiping¹³

Affiliation:

1. Department of Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Smithville, TX;

2. Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX; and

3. University of Texas Graduate School of Biomedical Sciences, Houston, TX

Abstract

Key Points Mouse Dnmt3a R878H (human R882H) mutant protein inhibits wild-type Dnmt3a/Dnmt3b in murine ES cells, suggesting dominant-negative effects.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/25/4086/1371378/4086.pdf

Reference22 articles.

1. DNMT3A mutations in acute myeloid leukemia.;Ley;N Engl J Med,2010

2. Array-based genomic resequencing of human leukemia.;Yamashita;Oncogene,2010

3. Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia.;Yan;Nat Genet,2011

4. Recurrent DNMT3A mutations in patients with myelodysplastic syndromes.;Walter;Leukemia,2011

5. DNMT3A mutational analysis in primary myelofibrosis, chronic myelomonocytic leukemia and advanced phases of myeloproliferative neoplasms.;Abdel-Wahab;Leukemia,2011

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