High NPM1-mutant allele burden at diagnosis predicts unfavorable outcomes in de novo AML-Reference-Cited by-同舟云学术

High NPM1-mutant allele burden at diagnosis predicts unfavorable outcomes in de novo AML

Published:2018-06-21 Issue:25 Volume:131 Page:2816-2825
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Patel Sanjay S.¹,Kuo Frank C.¹,Gibson Christopher J.²,Steensma David P.²,Soiffer Robert J.²,Alyea Edwin P.²,Chen Yi-Bin A.³,Fathi Amir T.³,Graubert Timothy A.³,Brunner Andrew M.³,Wadleigh Martha²,Stone Richard M.²,DeAngelo Daniel J.²,Nardi Valentina⁴,Hasserjian Robert P.⁴,Weinberg Olga K.¹⁵

Affiliation:

1. Department of Pathology, Brigham and Women’s Hospital, Boston, MA;

2. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA;

3. Massachusetts General Hospital Cancer Center, Boston, MA;

4. Department of Pathology, Massachusetts General Hospital, Boston, MA; and

5. Department of Pathology, Boston Children’s Hospital, Boston, MA

Abstract

Key Points High NPM1-mutant allele burden at diagnosis is associated with poor clinical outcome in de novo AML. The adverse effect of high NPM1-mutant allele burden is independent of comutations and clinical variables.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/131/25/2816/1466266/blood828467.pdf

Reference32 articles.

1. IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication;Paschka;J Clin Oncol,2010

2. Prognostic relevance of integrated genetic profiling in acute myeloid leukemia;Patel;N Engl J Med,2012

3. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia;Ley;N Engl J Med,2013

4. Prognostic significance of NPM1 mutations in the absence of FLT3-internal tandem duplication in older patients with acute myeloid leukemia: a SWOG and UK National Cancer Research Institute/Medical Research Council report;Ostronoff;J Clin Oncol,2015

Cited by 67 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Molecular characteristics of NPM1 mutations in AML patients using targeted NGS;Alexandria Journal of Medicine;2024-08-26

2. Molecular, clinical, and therapeutic determinants of outcome in NPM1-mutated AML;Blood;2024-08-15

3. Disparities in Palliative Care Use for Patients With Blood Cancer Who Died in the Hospital;American Journal of Hospice and Palliative Medicine®;2024-05-27

4. Epigenenomic and transcriptomic characterization ofNPM1-mutated CN-AML subtypes;2024-05-10

5. Clinical prognostic value of different NPM1 mutations in acute myeloid leukemia patients;Annals of Hematology;2024-05-09