High NPM1-mutant allele burden at diagnosis predicts unfavorable outcomes in de novo AML

Author:

Patel Sanjay S.1,Kuo Frank C.1,Gibson Christopher J.2,Steensma David P.2,Soiffer Robert J.2,Alyea Edwin P.2,Chen Yi-Bin A.3,Fathi Amir T.3,Graubert Timothy A.3,Brunner Andrew M.3,Wadleigh Martha2,Stone Richard M.2,DeAngelo Daniel J.2,Nardi Valentina4,Hasserjian Robert P.4,Weinberg Olga K.15

Affiliation:

1. Department of Pathology, Brigham and Women’s Hospital, Boston, MA;

2. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA;

3. Massachusetts General Hospital Cancer Center, Boston, MA;

4. Department of Pathology, Massachusetts General Hospital, Boston, MA; and

5. Department of Pathology, Boston Children’s Hospital, Boston, MA

Abstract

Key Points High NPM1-mutant allele burden at diagnosis is associated with poor clinical outcome in de novo AML. The adverse effect of high NPM1-mutant allele burden is independent of comutations and clinical variables.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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