Self-repopulating recipient bone marrow resident macrophages promote long-term hematopoietic stem cell engraftment

Author:

Kaur Simranpreet12ORCID,Raggatt Liza J.12,Millard Susan M.12ORCID,Wu Andy C.12,Batoon Lena12,Jacobsen Rebecca N.12,Winkler Ingrid G.12ORCID,MacDonald Kelli P.3ORCID,Perkins Andrew C.12,Hume David A.12,Levesque Jean-Pierre12ORCID,Pettit Allison R.12ORCID

Affiliation:

1. Mater Research Institute–The University of Queensland, Faculty of Medicine, The University of Queensland, Woolloongabba, QLD, Australia;

2. Translational Research Institute, Woolloongabba, QLD, Australia; and

3. QIMR Berghofer Medical Research Institute, Herston, QLD, Australia

Abstract

Key Points Recipient macrophages persist in hematopoietic tissues and self-repopulate via in situ proliferation after syngeneic transplantation. Targeted depletion of recipient CD169+ macrophages after transplant impaired long-term bone marrow engraftment of hematopoietic stem cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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